Abstract
Cancer cells, as with most mammalian cells, depend on a continuous supply of glucose; not only as a precursor of glycoproteins, triglycerides and glycogen, but also as an important source of energy. This review concentrates on GLUT transporter expression in both normal and cancerous classical sex-steroid hormone tissues (i.e. breast, uterus, ovary, testis and prostate, among others). Given the importance of estrogen, progesterone and androgens in carcinogenesis, as well as in survival and propagation of these cancers, this review also highlights the current literature on hormone regulation of glucose transporters and on the role of hypoxia in their expression. Furthermore, the recent explosion of information on the newer GLUT6-12 family members, a brief overview on their function and general expression has been included. Finally, an insight into the use of glucose transporters as markers of cancer progression and clinical outcome is also discussed.
Keywords: GLUT, estrogen, progesterone, testosterone, androgen, fructose, uterus, ovary, breast, prostate
Current Vascular Pharmacology
Title: Glucose Transporters in Sex Steroid Hormone Related Cancer
Volume: 7 Issue: 4
Author(s): Francisco Nualart, Maria de los Angeles Garcia, Rodolfo A. Medina and Gareth I. Owen
Affiliation:
Keywords: GLUT, estrogen, progesterone, testosterone, androgen, fructose, uterus, ovary, breast, prostate
Abstract: Cancer cells, as with most mammalian cells, depend on a continuous supply of glucose; not only as a precursor of glycoproteins, triglycerides and glycogen, but also as an important source of energy. This review concentrates on GLUT transporter expression in both normal and cancerous classical sex-steroid hormone tissues (i.e. breast, uterus, ovary, testis and prostate, among others). Given the importance of estrogen, progesterone and androgens in carcinogenesis, as well as in survival and propagation of these cancers, this review also highlights the current literature on hormone regulation of glucose transporters and on the role of hypoxia in their expression. Furthermore, the recent explosion of information on the newer GLUT6-12 family members, a brief overview on their function and general expression has been included. Finally, an insight into the use of glucose transporters as markers of cancer progression and clinical outcome is also discussed.
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Cite this article as:
Nualart Francisco, Garcia de los Angeles Maria, Medina A. Rodolfo and Owen I. Gareth, Glucose Transporters in Sex Steroid Hormone Related Cancer, Current Vascular Pharmacology 2009; 7 (4) . https://dx.doi.org/10.2174/157016109789043928
DOI https://dx.doi.org/10.2174/157016109789043928 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
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