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Current Alzheimer Research


ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Clinical Trajectories and Biological Features of Primary Progressive Aphasia (PPA)

Author(s): E. J. Rogalski and M. M. Mesulam

Volume 6, Issue 4, 2009

Page: [331 - 336] Pages: 6

DOI: 10.2174/156720509788929264

Price: $65


Primary Progressive Aphasia (PPA) is a neurodegenerative syndrome characterized by a gradual dissolution of language, but relative sparing of other cognitive domains during the initial stages of the disease. Research has led to substantial progress in understanding the clinical characteristics, genetics, and neuropathology of this syndrome. This article reviews the clinical criteria for diagnosing PPA, discusses the utility of defining the mild cognitive impairment (MCI) stage of PPA, and highlights some of the more recent research advances particularly in the area of pathology and genetics.

Keywords: Frontotemporal dementia, dementia, anomia, semantic dementia, progressive nonfluent aphasia, primary progressive aphasia, frontotemporal lobar degeneration

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