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Mini-Reviews in Organic Chemistry


ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Synthesis of Organic Carbamates without Using Phosgene: Carbonylation of Amines with Carbonic Acid Diesters

Author(s): M. Carafa and E. Quaranta

Volume 6, Issue 3, 2009

Page: [168 - 183] Pages: 16

DOI: 10.2174/157019309788922720

Price: $65


Aminolysis of organic carbonates is a suitable phosgene-free synthetic route to carbamate esters. The paper reviews recent advances in this field. Emphasis is laid on the reaction of amines with industrially relevant carbonic acid diesters, (MeO)2CO, (PhO)2CO, MeOC(O)OPh, currently obtainable without using phosgene. The carbonylation process may require a catalyst. The use of effective catalytic systems is highlighted and their mode of action is discussed.

Keywords: Carbamates, organic carbonates, phosgene substitution, carbonylation, catalysis

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