Abstract
Phospholipases A2 enzymes are found in many biological sources, including snake venoms. Here we reviewed aspects of PLA2s including biological and structural features, interaction with binding receptors, inhibitors used on structure- function relationship studies and highlighting the mechanism of action and role of the snake venom PLA2s products, the lysophosphatidylcholine.
Keywords: Phospholipases A2, snake venom, mechanism of action, inhibitors, lysophosphatidylcholine, binding receptors
Protein & Peptide Letters
Title: Structural and Pharmacological Features of Phospholipases A2 from Snake Venoms
Volume: 16 Issue: 8
Author(s): Rafael Cisne de Paula, Helena Carla Castro, Carlos Rangel Rodrigues, Paulo Assis Melo and Andre Lopes Fuly
Affiliation:
Keywords: Phospholipases A2, snake venom, mechanism of action, inhibitors, lysophosphatidylcholine, binding receptors
Abstract: Phospholipases A2 enzymes are found in many biological sources, including snake venoms. Here we reviewed aspects of PLA2s including biological and structural features, interaction with binding receptors, inhibitors used on structure- function relationship studies and highlighting the mechanism of action and role of the snake venom PLA2s products, the lysophosphatidylcholine.
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Cite this article as:
de Paula Cisne Rafael, Castro Carla Helena, Rodrigues Rangel Carlos, Melo Assis Paulo and Fuly Lopes Andre, Structural and Pharmacological Features of Phospholipases A2 from Snake Venoms, Protein & Peptide Letters 2009; 16 (8) . https://dx.doi.org/10.2174/092986609788923365
DOI https://dx.doi.org/10.2174/092986609788923365 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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