Abstract
The present paper reviews and discusses selectivity of ABCC4 (MRP4), ABCC5 (MRP5) and ABCC11 (MRP8) as cellular efflux pumps for cAMP and cGMP. These transporters are potential drug targets for selective modulation of cyclic nucleotide action.
Keywords: cGMP, cAMP, ABCC4, ABCC5, ABCC11, transport selectivity
Mini-Reviews in Medicinal Chemistry
Title: Cellular Efflux of cAMP and cGMP - A Question about Selectivity
Volume: 9 Issue: 8
Author(s): Georg Sager and Aina Westrheim Ravna
Affiliation:
Keywords: cGMP, cAMP, ABCC4, ABCC5, ABCC11, transport selectivity
Abstract: The present paper reviews and discusses selectivity of ABCC4 (MRP4), ABCC5 (MRP5) and ABCC11 (MRP8) as cellular efflux pumps for cAMP and cGMP. These transporters are potential drug targets for selective modulation of cyclic nucleotide action.
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Cite this article as:
Sager Georg and Ravna Westrheim Aina, Cellular Efflux of cAMP and cGMP - A Question about Selectivity, Mini-Reviews in Medicinal Chemistry 2009; 9 (8) . https://dx.doi.org/10.2174/138955709788681654
DOI https://dx.doi.org/10.2174/138955709788681654 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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