Abstract
The mechanism by which Hsp40 and other molecular chaperones recognize and interact with non-native polypeptides is a fundamental question, as is how Hsp40 co-operates with Hsp70 to facilitate protein folding. Years of structural studies of Hsp40 from yeast and other species, conducted using X-ray protein crystallography, NMR and small-angle X-ray scattering, have shed light on the mechanisms how Hsp40 functions as a molecular chaperone and how Hsp40- Hsp70 pair promotes protein folding, protein transport and degradation. This review provides a discussion of recent structural studies of Hsp40s and their functional implications.
Keywords: Molecular chaperone, Hsp40, Hsp70, J-domain, peptide-binding fragment, protein structure, Sis1, Ydj1
Protein & Peptide Letters
Title: Heat Shock Protein 40: Structural Studies and Their Functional Implications
Volume: 16 Issue: 6
Author(s): Jingzhi Li, Xinguo Qian and Bingdong Sha
Affiliation:
Keywords: Molecular chaperone, Hsp40, Hsp70, J-domain, peptide-binding fragment, protein structure, Sis1, Ydj1
Abstract: The mechanism by which Hsp40 and other molecular chaperones recognize and interact with non-native polypeptides is a fundamental question, as is how Hsp40 co-operates with Hsp70 to facilitate protein folding. Years of structural studies of Hsp40 from yeast and other species, conducted using X-ray protein crystallography, NMR and small-angle X-ray scattering, have shed light on the mechanisms how Hsp40 functions as a molecular chaperone and how Hsp40- Hsp70 pair promotes protein folding, protein transport and degradation. This review provides a discussion of recent structural studies of Hsp40s and their functional implications.
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Cite this article as:
Li Jingzhi, Qian Xinguo and Sha Bingdong, Heat Shock Protein 40: Structural Studies and Their Functional Implications, Protein & Peptide Letters 2009; 16 (6) . https://dx.doi.org/10.2174/092986609788490159
DOI https://dx.doi.org/10.2174/092986609788490159 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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