Abstract
The first synthesis of lissoclimide-type alkaloids is described. Starting from commercial (+)-sclareolide, the aldehyde γ-bicyclohomofarnesal is synthesized and coupled, through an aldol reaction, with succinimide. The antitumor activity of several lissoclimide analogues is also reported.
Keywords: Lissoclimide, Haterumaimide, Diterpene, Alkaloid, Cytotoxicity, Aldol
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