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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Diagnosis and Therapy of Autoimmune Hepatitis

Author(s): Alessandro Granito, Paolo Muratori, Silvia Ferri, Georgios Pappas, Chiara Quarneti, Marco Lenzi, Francesco B. Bianchi and Luigi Muratori

Volume 9, Issue 7, 2009

Page: [847 - 860] Pages: 14

DOI: 10.2174/138955709788452676

Price: $65


Autoimmune hepatitis (AIH) is a chronic progressive hepatitis, characterized by interface hepatitis with lymphoplasmacellular infiltrates on liver biopsy, high serum globulin level and circulating autoantibodies. It is classified into two types, according to autoantibody profile: type 1 is characterized by anti-nuclear (ANA) and/or anti-smooth muscle (SMA) antibodies; type 2 by anti-liver kidney microsomal type 1 (anti-LKM-1) antibodies. AIH affects all ages, may be asymptomatic, frequently has an acute onset, and can present as fulminant hepatitis. The diagnosis of AIH is based on a scoring system codified by an international consensus. Corticosteroids alone or in conjunction with azathioprine is the treatment of choice in patients with AIH and results in remission induction in over 80% of patients. Alternative proposed strategies in patients who have failed to achieve remission on standard therapy or patients with drug toxicity include the use of cyclosporine, tacrolimus, budesonide or mycophenolate mofetil. Liver transplantation is the treatment of choice in managing decompensated disease, however AIH can recur or develop de novo after liver transplantation.

Keywords: Autoimmune hepatitis, autoantibodies, autoimmune liver disease, immunosuppressive treatment

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