Generic placeholder image

Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

New Insights into the Pleiotropic Effects of Statins for Stroke Prevention

Author(s): Alessandro Pezzini, Elisabetta Del Zotto, Irene Volonghi, Alessia Giossi, Paolo Costa and Alessandro Padovani

Volume 9, Issue 7, 2009

Page: [794 - 804] Pages: 11

DOI: 10.2174/138955709788452658

Price: $65


There is compelling evidence that treatment with 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors - “statins” - the most important class of lipid lowering agents, reduces ischemic stroke incidence independent on their effect on serum cholesterol levels. In this review, the non-lipid-mediated - “pleiotropic” - effects of statins as well as their potential implication in developing new treatment strategies for stroke prevention will be discussed.

Keywords: HMG-CoA reductase inhibitors, stroke, pleiotropic effects

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy