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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Discovery of Novel Plant Peptides as Strong Inhibitors of Metalloproteinases

Author(s): Dina M. Carrilho, Isabel C. Duarte, Rita Francisco, Candido P.P. Ricardo and Maria C. Duque-Magalhaes

Volume 16, Issue 5, 2009

Page: [543 - 551] Pages: 9

DOI: 10.2174/092986609788167789

Price: $65


Five novel metalloproteinase protein inhibitors (MPIs) with molecular mass between 5.6 and 8.9 kDa and acid/neutral pI were detected in lupin seeds and exhibited strong inhibitory activities against thermolysin and/or gelatinase B. These novel peptides constitute not only the first MPIs described in plants but also the first plant peptides with inhibitory activity against a matrixin.

Keywords: Gelatinase B, lupin quiescent seed, matrixin peptide inhibitor, metalloproteinase protein inhibitor (MPI), thermolysin

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