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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Diphenylpentane Skeleton as a Multi-Template for Steroid Skeleton- Recognizing Receptors/Enzymes

Author(s): Shinnosuke Hosoda, Daisuke Matsuda, Hiroshi Tomoda and Yuichi Hashimoto

Volume 9 , Issue 5 , 2009

Page: [572 - 580] Pages: 9

DOI: 10.2174/138955709788167574

Price: $65

Abstract

As an example of a multi-template approach, we focused on the 3,3-diphenylpentane (DPP) skeleton, which has been demonstrated to act as a steroid skeleton substitute. Various ligands for nuclear receptors (NRs), including vitamin D receptor (VDR), androgen receptor (AR) and farnesoid X receptor (FXR), and inhibitors of steroid metabolismrelated enzymes, including 5α-reductase and HMG-CoA reductase (HMGR), have been efficiently created by introducing various substituents onto the DPP skeleton.

Keywords: Multi-template, steroids, diphenylpentane skeleton, steroid skeleton substitute, nuclear receptor, vitamin D receptor, androgen receptor, farnesoid X receptor, 5α-reductase, HMG-CoA reductase


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