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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Cannabinoid System in Neurodegeneration: New Perspectives in Alzheimers Disease

Author(s): N. E. Campillo and J. A. Paez

Volume 9, Issue 5, 2009

Page: [539 - 559] Pages: 21

DOI: 10.2174/138955709788167628

Price: $65


Alzheimers disease is a chronic and progressive neurodegenerative disorder. The presence of functional cannabinoid CB2 receptors in central nervous system (CNS) has provoked that this receptor and its agonist ligands are now considered as promising pharmacological targets for neurological diseases. Herein, we review the evidences supporting the potential role of the ECS as a therapeutic target, focused on CB2 receptor and its ligands, for the treatment of Alzheimer s disease.

Keywords: Cannabinoid, endocannabinoid, cannabinoid receptors, alzheimer's disease, dementia, CB2 agonist

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