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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis of New 1, 4-Dihydropyridines by Addition-Rearrangement Process with Imine Derivatives and β-Ketoester as Starting Materials in Solvent-Free Conditions (SUPPORTING INFORMATION)

Author(s): Xueming Chen, Xiaoguang Huang, Yunyun Chen, Feng He and Xingshu Li

Volume 6, Issue 3, 2009

Page: [213 - 218] Pages: 6

DOI: 10.2174/157017809787893082

Price: $65


N-substituted 1,4-dihydropyridines bearing a carboxyl group at the 4-position were synthesized in solvent-free conditions with Cu2+ as the catalyst, imine and β-ketoester as starting materials. The possible mechanism which consists of addition-rearrangement process was proposed and examined by the reaction of isolated product of first addition to β- ketoester.

Keywords: Dihydropyridines, addition-rearrangement, Cu2+-catalyzed, imines, β-ketoester, solvent-free

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