Abstract
The interest in the microwave assisted organic synthesis has been growing during the recent years. It results from an increasing knowledge of fundamentals of the dielectric heating theory, availability of an equipment designed especially for the laboratory use as well as the discovery of the special techniques of the microwave syntheses. The efficiency of microwave flash-heating chemistry in dramatically reducing reaction times (reduced from days and hours to minutes and seconds) has recently been proven in several different fields of organic chemistry and this aspect is of great importance in high-speed combinatorial and medicinal chemistry. In this contribution, the current state of the art is summarized providing examples of the most recent applications in the field of microwave assisted synthesis of biologically active compounds both in heterocyclic and in peptide and peptidomimetic optimization.
Keywords: Microwave, dielectric heating, combinatorial chemistry, medicinal chemistry, heterocycles, peptides, peptidomimetic
Mini-Reviews in Medicinal Chemistry
Title: Microwave Assisted Synthesis: A New Technology in Drug Discovery
Volume: 9 Issue: 3
Author(s): V. Santagada, F. Frecentese, E. Perissutti, F. Fiorino, B. Severino and G. Caliendo
Affiliation:
Keywords: Microwave, dielectric heating, combinatorial chemistry, medicinal chemistry, heterocycles, peptides, peptidomimetic
Abstract: The interest in the microwave assisted organic synthesis has been growing during the recent years. It results from an increasing knowledge of fundamentals of the dielectric heating theory, availability of an equipment designed especially for the laboratory use as well as the discovery of the special techniques of the microwave syntheses. The efficiency of microwave flash-heating chemistry in dramatically reducing reaction times (reduced from days and hours to minutes and seconds) has recently been proven in several different fields of organic chemistry and this aspect is of great importance in high-speed combinatorial and medicinal chemistry. In this contribution, the current state of the art is summarized providing examples of the most recent applications in the field of microwave assisted synthesis of biologically active compounds both in heterocyclic and in peptide and peptidomimetic optimization.
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Cite this article as:
Santagada V., Frecentese F., Perissutti E., Fiorino F., Severino B. and Caliendo G., Microwave Assisted Synthesis: A New Technology in Drug Discovery, Mini-Reviews in Medicinal Chemistry 2009; 9 (3) . https://dx.doi.org/10.2174/1389557510909030340
DOI https://dx.doi.org/10.2174/1389557510909030340 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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