The Role of WNT in Rheumatoid Arthritis and its Therapeutic Implication

Kazushi      Imai; Tadashige      Chiba; Genta      Maeda; Masako      Morikawa

Abstract

Rheumatoid arthritis (RA) is a systematic inflammatory and intractable disease, which progressively affects multiple joints. Recent findings strongly suggest a key role of WNT signaling in the disease initiation and progression. In this review, we discuss the role and possibility of treatment by targeting WNT signaling.

Keywords: WNT, rheumatoid arthritis, FRP, β-catenin, synovium, matrix metalloproteinase

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