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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

The Role of WNT in Rheumatoid Arthritis and its Therapeutic Implication

Author(s): Kazushi Imai, Tadashige Chiba, Genta Maeda and Masako Morikawa

Volume 9, Issue 3, 2009

Page: [318 - 323] Pages: 6

DOI: 10.2174/1389557510909030318

Price: $65


Rheumatoid arthritis (RA) is a systematic inflammatory and intractable disease, which progressively affects multiple joints. Recent findings strongly suggest a key role of WNT signaling in the disease initiation and progression. In this review, we discuss the role and possibility of treatment by targeting WNT signaling.

Keywords: WNT, rheumatoid arthritis, FRP, β-catenin, synovium, matrix metalloproteinase

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