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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Molecular Modeling Studies of ABC Transporters Involved in Multidrug Resistance

Author(s): Aina Westrheim Ravna and Georg Sager

Volume 9, Issue 2, 2009

Page: [186 - 193] Pages: 8

DOI: 10.2174/138955709787316065

Price: $65


Multidrug resistance (MDR) is a limitation to cancer chemotherapy, antibiotic treatment and HIV medication. Molecular models of the ABC transporters ABCB1 (P-glycoprotein), ABCC4 (multidrug resistance protein 4 (MRP4)) and ABCC5 (MRP5), which are involved in MDR, may aid in the development of drugs inhibiting anticancer agents efflux.

Keywords: Molecular modeling, P-glycoprotein/ABCB1, MRP4/ABCC4, MRP5/ABCC5, multidrug resistance

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