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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Antitumor Activity of Novel 4-Chloro-3-Arylmaleimide Derivatives

Author(s): Guiqing Xu, Qiaojun He, Bo Yang and Yongzhou Hu

Volume 6, Issue 1, 2009

Page: [51 - 55] Pages: 5

DOI: 10.2174/157018009787158490

Price: $65


A novel series of 4-chloro-3-arylmaleimide derivatives have been synthesized and evaluated for their cytotoxicity in vitro against human leukemia cell line and four human solid cancer cell lines. Most compounds showed high or mediate activity against the cancer cell lines when compared with bisindolylmaleimide. Among them, 4b is the most promising compound.

Keywords: 4-chloro-3-arylmaleimide, Synthesis, Antitumor activity

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