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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Structural and Morphological Studies of Cationic Liposomes-DNA Complexes

Author(s): Yan Sun, Itziar Migueliz, Gemma Navarro and Conchita Tros de Ilarduya

Volume 6, Issue 1, 2009

Page: [33 - 37] Pages: 5

DOI: 10.2174/157018009787158571

Price: $65

Abstract

In this study we have prepared and characterized, in terms of structure and morphology, different cationic lipid- DNA complexes (lipoplexes). Condensation studies showing the ability of cationic lipids to condense DNA are presented. The effect of the presence of serum and the ligand transferrin (Tf) has also been evaluated. Studies of negative stain transmission electron microscopy (TEM), infrared spectroscopy (FTIR), differential thermal analysis (DTA) and X-ray diffractometry have shown stable complexes with different morphology and structural rearrangements.

Keywords: Cationic liposomes, Gene delivery, Lipoplexes, Structure, Morphology


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