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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Role of Nitric Oxide in Physiology and Pathology of the Gastrointestinal Tract

Author(s): A. Stanek, A. Gadowska-Cicha, K. Gawron, T. Wielkoszynski, B. Adamek, G. Cieslar, A. Wiczkowski and A. Sieron

Volume 8, Issue 14, 2008

Page: [1549 - 1560] Pages: 12

DOI: 10.2174/138955708786786462

Price: $65


In this paper the physiological role of NO and isoforms of NOS in the gastrointestinal tract and the involvement of NO in pathological processes of digestive tract as well as the perspective of therapeutic use of NO-donating drugs and selective inhibitors of phosphodiesterase in the treatment of gastric diseases were presented.

Keywords: Nitric oxide, constitutive nitric oxide synthase, inducible nitric oxide synthase, gastrointestinal tract, inflammatory process, malignant transformations, NO-donor drugs, phosphodiesterase inhibitors

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