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Current Immunology Reviews (Discontinued)


ISSN (Print): 1573-3955
ISSN (Online): 1875-631X

The Expanding Universe of γ δ T Lymphocytes: Subsets, Generation and Function

Author(s): Serena Meraviglia, Nadia Caccamo, Carmela La Mendola, Giuliana Guggino and Francesco Dieli

Volume 4, Issue 4, 2008

Page: [183 - 189] Pages: 7

DOI: 10.2174/157339508786447940

Price: $65


γδ T cells which express the Vγ9 and Vδ2 gene products are unique to primates and represent only a minor population of peripheral blood T lymphocytes. They recognize nonpeptidic phosphoantigens in an MHC-unrestricted fashion and show low dependence on costimulation. The ability of Vγ9Vδ2 T cells to develop immunological memory remains debated. Vγ9Vδ2 T cells are able to mount both immediate effector functions and memory anamnestic responses upon microbial reinfection, suggestive of the existence of different functional subsets. However, how Vγ9Vδ2 T cells mediate the different facets of a memory response remains largely obscure. In this review we highlight recent findings that demonstrate that Vγ9Vδ2 cells are a very heterogeneous population of T lymphocytes and possess phenotypic and functional features very close to those of conventional αβ T lymphocytes: they comprise distinct naive, memory and effector populations that can be distinguished on the basis of surface markers expression, migratory properties and effector functions.

Keywords: Vα9Vδ2 T lymphocytes, phosphoantigens, central memory, effector memory, chemokines, antibody response

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