The Exploding Field of the HCV Polymerase Non-Nucleoside Inhibitors: Summary of a First Generation Compounds

Enzo      Tramontano

Abstract

The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) is strictly essential for viral replication and it has been used as viral target for anti-HCV drug development. All small molecules which have been identified to be selective non-nucleoside inhibitors (NNI) of the HCV RdRp to date are reported.

Keywords: HCV, RNA dependent RNA polymerase (RdRp), non-nucleoside, inhibition, drug development, antiviral, NNI, small molecules