Synthesis of Marine Natural Products with Antimalarial Activity

Ines      Mancini; Graziano      Guella; Andrea      Defant

Abstract

The role played by synthetic organic chemistry of marine metabolites as potential leads for drug discovery of antimalarial agents is discussed. Syntheses of the most promising molecules are summarized, with emphasis on structureactivity relationship (SAR) studies and their mechanism of action.

Keywords: Natural products, marine metabolites, drug discovery, synthesis, retrosynthetic analysis, antiprotozoal, antimalarial, antiplasmodial