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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Synthesis of Marine Natural Products with Antimalarial Activity

Author(s): Ines Mancini, Graziano Guella and Andrea Defant

Volume 8, Issue 12, 2008

Page: [1265 - 1284] Pages: 20

DOI: 10.2174/138955708786141007

Price: $65


The role played by synthetic organic chemistry of marine metabolites as potential leads for drug discovery of antimalarial agents is discussed. Syntheses of the most promising molecules are summarized, with emphasis on structureactivity relationship (SAR) studies and their mechanism of action.

Keywords: Natural products, marine metabolites, drug discovery, synthesis, retrosynthetic analysis, antiprotozoal, antimalarial, antiplasmodial

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