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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

The Role of Structure Activity Relationship Studies in the Search for New GABA Uptake Inhibitors

Author(s): Katarzyna Kulig and Marta Szwaczkiewicz

Volume 8, Issue 12, 2008

Page: [1214 - 1223] Pages: 10

DOI: 10.2174/138955708786141070

Price: $65


γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system (CNS). A decrease in GABAergic neurotransmission seems to be involved in neurological pathologies such as epilepsy, anxiety and pain. This review is focus on structure activity relationship studies aiming the search for new GABA uptake inhibitors.

Keywords: γ-Aminobutyric acid, GABA, GABA uptake antagonist, GABA transporter, GAT

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