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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Efficient Cleavage of Bid and Procaspase-7 by Caspase-2 at Lower pH

Author(s): Pratap Karki, Giri Raj Dahal, Song Yub Shin, Jung Sup Lee, Byungyun Cho and Il-Seon Park

Volume 15, Issue 10, 2008

Page: [1044 - 1049] Pages: 6

DOI: 10.2174/092986608786071193

Price: $65


The activity of caspase-2 was examined under varying biochemical conditions with the synthetic and protein substrates, Bid and procaspase-7. The results indicate that it was largely influenced by pH which might be one reason behind the inconsistency for the cleavage of its established substrates during caspase-2-induced apoptosis.

Keywords: Caspase-2, caspase-8, pH, salt, Bid, procaspase-7

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