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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Design of Selective G-quadruplex Ligands as Potential Anticancer Agents

Author(s): Jia-Heng Tan, Lian-Quan Gu and Jian-Yong Wu

Volume 8, Issue 11, 2008

Page: [1163 - 1178] Pages: 16

DOI: 10.2174/138955708785909880

Price: $65


G-quadruplex structures are promising targets for design of cancer drugs with high selectivity and low toxicity. This review provides an update of the progress made over the last few years in the design of selective G-quadruplex ligands, and a comprehensive summary of the major design strategies and structural characteristics.

Keywords: G-quadruplex, G-quartet, ligands, substituted derivatives, affinity and selectivity, DNA interactions, telomerase inhibition

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