Abstract
Analysis of the amino acid composition of prion protein using a newly developed program for radar-chart deviation analysis has identified an abnormality or irregularity of the N-terminal flexible domain. Aromatic amino acids Trp and His together with Gly are abnormally abounding in this Nterminal domain, in which octapeptide GQPHGGGW is connected four times in tandem. This tetrarepeat structure has been suggested to be essential for the prion protein not only to play an intrinsic functional role in the physiological condition, but also to bring on structural abnormalities in prion disease.
Keywords: Prion protein, prion disease, amino acid composition, radar-chart deviation analysis, octapeptide repeat structure
Protein & Peptide Letters
Title: Radar Chart Deviation Analysis of Prion Protein Amino Acid Composition Defines Characteristic Structural Abnormalities of the N-Terminal Octapeptide Tandem Repeat
Volume: 15 Issue: 9
Author(s): Satoru Yokotani, Takeru Nose, Yuji Horiuchi, Ayami Matsushima and Yasuyuki Shimohigashi
Affiliation:
Keywords: Prion protein, prion disease, amino acid composition, radar-chart deviation analysis, octapeptide repeat structure
Abstract: Analysis of the amino acid composition of prion protein using a newly developed program for radar-chart deviation analysis has identified an abnormality or irregularity of the N-terminal flexible domain. Aromatic amino acids Trp and His together with Gly are abnormally abounding in this Nterminal domain, in which octapeptide GQPHGGGW is connected four times in tandem. This tetrarepeat structure has been suggested to be essential for the prion protein not only to play an intrinsic functional role in the physiological condition, but also to bring on structural abnormalities in prion disease.
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Yokotani Satoru, Nose Takeru, Horiuchi Yuji, Matsushima Ayami and Shimohigashi Yasuyuki, Radar Chart Deviation Analysis of Prion Protein Amino Acid Composition Defines Characteristic Structural Abnormalities of the N-Terminal Octapeptide Tandem Repeat, Protein & Peptide Letters 2008; 15 (9) . https://dx.doi.org/10.2174/092986608785849182
DOI https://dx.doi.org/10.2174/092986608785849182 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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