Abstract
Mastoparan, a toxic peptide from wasp venom, induces various biological functions including histamine release from rat peritoneal mast cells. Here we report that, for the activation of mast cells by mastoparan, at least two positively charged side chains are required on the hydrophilic side of the amphiphilic structure of the peptide. The present results are expected to be utilized for the bioinformatic and comprehensive identification of endogenous mast cell-stimulating cryptides.
Keywords: Mastoparan, exocytosis, peritoneal mast cells, β-hexosaminidase, lactate dehydrogenase, G protein
Protein & Peptide Letters
Title: Elucidation of Structural Requirements of Mastoparan for Mast Cell Activation- Toward the Comprehensive Prediction of Cryptides Acting on Mast Cells
Volume: 15 Issue: 9
Author(s): H. Mukai, Y. Suzuki, Y. Kiso and E. Munekata
Affiliation:
Keywords: Mastoparan, exocytosis, peritoneal mast cells, β-hexosaminidase, lactate dehydrogenase, G protein
Abstract: Mastoparan, a toxic peptide from wasp venom, induces various biological functions including histamine release from rat peritoneal mast cells. Here we report that, for the activation of mast cells by mastoparan, at least two positively charged side chains are required on the hydrophilic side of the amphiphilic structure of the peptide. The present results are expected to be utilized for the bioinformatic and comprehensive identification of endogenous mast cell-stimulating cryptides.
Export Options
About this article
Cite this article as:
Mukai H., Suzuki Y., Kiso Y. and Munekata E., Elucidation of Structural Requirements of Mastoparan for Mast Cell Activation- Toward the Comprehensive Prediction of Cryptides Acting on Mast Cells, Protein & Peptide Letters 2008; 15 (9) . https://dx.doi.org/10.2174/092986608785849362
DOI https://dx.doi.org/10.2174/092986608785849362 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
Call for Papers in Thematic Issues
Advancing the Understanding of Regulatory Mechanisms and Diseases Through Biochemistry and Structural Biology
Modern research is increasingly interested in understanding the regulatory mechanisms and diseases through various integrative approaches. Biochemistry and structural biology offer valuable atomic-level insights that help unravel the complexities of cellular regulatory mechanisms and their association with health and disease. The unique advantage of these fields is that they provide ...read more
Therapeutic Proteins and Peptides of Plant Origin
Plants are still the major repository of biologically active substances. In the last two decades, however, natural peptides and proteins of plant origin have gained increasing attention due to their pharmacological activities over a variety of human illnesses, including those mediated by infections and parasitosis and those involving different cellular ...read more
Related Journals

- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Can Combined Therapy Benefit Immune Checkpoint Blockade Response in Hepatocellular Carcinoma?
Anti-Cancer Agents in Medicinal Chemistry Stairway to Heaven or Hell? Perspectives and Limitations of Chagas Disease Chemotherapy
Current Topics in Medicinal Chemistry Modulators of Pain: Bv8 and Prokineticins
Current Neuropharmacology The Management of Gestational Diabetes
Current Diabetes Reviews Nuciferine Inhibits Skin Cutaneous Melanoma Cell Growth by Suppressing TLR4/NF-κB Signaling
Anti-Cancer Agents in Medicinal Chemistry Lessons from Darwin: Evolutionary Biologys Implications for Alzheimers Disease Research and Patient Care
Current Alzheimer Research Nitric Oxide as a Marker for Levo-Thyroxine Therapy in Subclinical Hypothyroid Patients
Current Vascular Pharmacology The Discovery and Development of Drug Combinations for the Treatment of Various Diseases from Patent Literature (1980-Present)
Current Topics in Medicinal Chemistry Vitamin D Deficiency, Prevalence and Treatment in Neonatal Period
Endocrine, Metabolic & Immune Disorders - Drug Targets TRAIL as Biomarker and Potential Therapeutic Tool for Cardiovascular Diseases
Current Drug Targets Atomistic Models for Free Energy Evaluation of Drug Binding to Membrane Proteins
Current Medicinal Chemistry Biomedical Applications of Gold Nanoparticles
Current Topics in Medicinal Chemistry Research Advances on Anticancer Effect of Licorice
Current Bioactive Compounds Structural and Functional Relationships Between GSK3α and GSK3β Proteins
Current Biotechnology Genetic Variability of Matrix Metalloproteinase Genes in Cardiovascular Disease
Current Topics in Medicinal Chemistry Glucosidase II and MRH-Domain Containing Proteins in the Secretory Pathway
Current Protein & Peptide Science Modulation of Signal-Transducing Function of Neuronal Membrane Na+,K by Endogenous Ouabain and Low-Power Infrared Radiation Leads to Pain Relief
Medicinal Chemistry Structure-based Design on Anticancer Drug Discovery
Current Topics in Medicinal Chemistry Non-cholesterol Sterols in the Diagnosis and Treatment of Dyslipidemias: A Review
Current Medicinal Chemistry Hydrofiber Dressing and Wound Repair: Review of the Literature and New Patents
Recent Patents on Inflammation & Allergy Drug Discovery