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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Simple and High-Yield Route to N-9-purinyl-acetic Acid Derivatives Coupled with Amino Acids

Author(s): Marie-Emmanuelle Million, Sylvie Radix, Sebastien Marrot, Magali Imbert and Joelle Paris

Volume 5, Issue 6, 2008

Page: [484 - 489] Pages: 6

DOI: 10.2174/157017808785740408

Price: $65


A facile route to synthesize amide type N-9-purinyl-acetic acid derivatives both in guanine and hypoxanthine series is described. The regioselective alkylation of the 6-chloro-purine derivatives followed by their conversion into guanine or hypoxanthine nucleus in mild acidic conditions, are the key steps that allow the efficient preparation of compounds with an acetic function coupled with various amino acids.

Keywords: Purinyl-acetic acid derivatives, peptide coupling, hypoxanthine, guanine

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