Recent Progress of Src Family Kinase Inhibitors as Anticancer Agents

Xin      Cao; Qi-Dong      You; Zhi-Yu      Li; Xiao-Jian      Wang; Xiao-Yun      Lu; Xiao-Rong      Liu; Dan      Xu; Bao      Liu

Abstract

Src family of protein tyrosine kinases (SFKs) play key roles in regulating signal transduction in cellular processes. However, hyper-activated SFKs lead to uncontrolled cell proliferation and cancers. Many SFKs inhibitors were designed and synthesized as anticancer agents in the past several years and great progress has been made. Herein, some predominant examples of SFKs inhibitors recently developed are reviewed and special attentions are paid to the most important ATP binding site inhibitors.

Keywords: Protein tyrosine kinases, Src family kinases, kinase domain, inhibitor, anticancer, drug design, SH2, SH3