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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Recent Progress of Src Family Kinase Inhibitors as Anticancer Agents

Author(s): Xin Cao, Qi-Dong You, Zhi-Yu Li, Xiao-Jian Wang, Xiao-Yun Lu, Xiao-Rong Liu, Dan Xu and Bao Liu

Volume 8, Issue 10, 2008

Page: [1053 - 1063] Pages: 11

DOI: 10.2174/138955708785740634

Price: $65


Src family of protein tyrosine kinases (SFKs) play key roles in regulating signal transduction in cellular processes. However, hyper-activated SFKs lead to uncontrolled cell proliferation and cancers. Many SFKs inhibitors were designed and synthesized as anticancer agents in the past several years and great progress has been made. Herein, some predominant examples of SFKs inhibitors recently developed are reviewed and special attentions are paid to the most important ATP binding site inhibitors.

Keywords: Protein tyrosine kinases, Src family kinases, kinase domain, inhibitor, anticancer, drug design, SH2, SH3

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