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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

From Cochlear Cell Death Pathways To New Pharmacological Therapies

Author(s): Jing Wang and Jean-Luc Puel

Volume 8, Issue 10, 2008

Page: [1006 - 1019] Pages: 14

DOI: 10.2174/138955708785740599

Price: $65


Ototoxic drugs, intense sound or age-related hearing loss recruit most of the apoptotic pathways, but also several additional enzymatic pathways which eventually result in cell death. Here, we discuss therapeutic strategies based on the inhibition of regulators or executors of apoptotic cell death pathways and on the use of antioxidants.

Keywords: Apoptosis, necrosis, cell death pathway, cochlea, therapeutic strategies, ototoxic drugs, intense sound, age-related hearing loss

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