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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Therapeutic Role of Zonisamide in Neuropsychiatric Disorders

Author(s): Muhammad U. Farooq, Philip W. Moore, Archit Bhatt, Rany Aburashed and Mounzer Y. Kassab

Volume 8, Issue 10, 2008

Page: [968 - 975] Pages: 8

DOI: 10.2174/138955708785740643

Price: $65


Zonisamide (ZNS), a sulfonamide antiepileptic drug, is indicated as an adjunct therapy for partial seizure disorders with and without secondary generalization. ZNS has a favorable pharmacokinetic profile because of its rapid absorption and high bioavailability. Its activity is related to the blockade of voltage gated sodium and calcium channels, modulation of central dopaminergic, GABAergic, and serotonergic functions, as well as inhibition of carbonic anhydrase and monoamine oxidase B. ZNS has potential efficacy for an array of neuropsychiatric disorders including migraine and other headache syndromes, neuropathic pain, Parkinsons disease, essential tremor, stroke, obesity, anxiety, bipolar and bingeeating disorders.

Keywords: zonisamide, seizure disorders, migraine, pain syndromes, movement disorders, neuroprotection, bipolar and anxiety disorders

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