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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Small Molecules Targeting p53 to Improve Antitumor Therapy

Author(s): G. L. Beretta, L. Gatti, V. Benedetti, P. Perego and F. Zunino

Volume 8, Issue 9, 2008

Page: [856 - 868] Pages: 13

DOI: 10.2174/138955708785132774

Price: $65


Small molecules targeting p53 represent an emerging group of potentially useful agents for the improvement of antitumor therapy. These modulators include agents that activate wild-type p53 or reactivate mutant p53 and inhibitors of p53 functions. Preclinical evidences support the interest of combination strategies with conventional antitumor agents.

Keywords: p53, nutlins, pifithrins, histone deacetylase inhibitors, ubiquitin ligase inhibitors, apoptosis, cancer cells, drug combination

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