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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Classification of Amine Type G-Protein Coupled Receptors with Feature Selection

Author(s): Qing-Bin Gao, Cheng Wu, Xiu-Qiang Ma, Jian Lu and Jia He

Volume 15, Issue 8, 2008

Page: [834 - 842] Pages: 9

DOI: 10.2174/092986608785203755

Price: $65


G-protein coupled receptors (GPCRs) are involved in various physiological processes. Therefore, classification of amine type GPCRs is important for proper understanding of their functions. Though some effective methods have been developed, it still remains unknown how many and which features are essential for this task. Empirical studies show that feature selection might address this problem and provide us with some biologically useful knowledge. In this paper, a feature selection technique is introduced to identify those relevant features of proteins which are potentially important for the prediction of amine type GPCRs. The selected features are finally accepted to characterize proteins in a more compact form. High prediction accuracy is observed on two data sets with different sequence similarity by 5-fold cross-validation test. The comparison with a previous method demonstrates the efficiency and effectiveness of the proposed method.

Keywords: G-protein coupled receptor, Feature selection, Protein classification, Support vector machine

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