From Dual Binding Site Acetylcholinesterase Inhibitors to Multi-Target-Directed Ligands (MTDLs): A Step Forward in the Treatment of Alzheimers Disease

Title: From Dual Binding Site Acetylcholinesterase Inhibitors to Multi-Target-Directed Ligands (MTDLs): A Step Forward in the Treatment of Alzheimers Disease

Volume: 8 Issue: 10

Author(s): Maria Laura Bolognesi, Anna Minarini, Michela Rosini, Vincenzo Tumiatti and Carlo Melchiorre

Affiliation:

Keywords: Dimeric compounds, bivalent ligands, multimodal therapeutics, multifunctional compounds, multifactorial diseases

Abstract: Alzheimers disease is a complex neurodegenerative disorder with a multifaceted pathogenesis. This fact has long halted the development of effective anti-Alzheimer drugs. Recently, however, basis for a therapeutic strategy based on multi-target-directed ligands has been formed. In this context, dual binding site acetylcholinesterase inhibitors represent a suitable starting point. The rational modification of their structures to provide them with additional biological properties has emerged as a successful approach.

Cite this article as:

Bolognesi Laura Maria, Minarini Anna, Rosini Michela, Tumiatti Vincenzo and Melchiorre Carlo, From Dual Binding Site Acetylcholinesterase Inhibitors to Multi-Target-Directed Ligands (MTDLs): A Step Forward in the Treatment of Alzheimers Disease, Mini-Reviews in Medicinal Chemistry 2008; 8(10) . https://dx.doi.org/10.2174/138955708785740652