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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

From Dual Binding Site Acetylcholinesterase Inhibitors to Multi-Target-Directed Ligands (MTDLs): A Step Forward in the Treatment of Alzheimers Disease

Author(s): Maria Laura Bolognesi, Anna Minarini, Michela Rosini, Vincenzo Tumiatti and Carlo Melchiorre

Volume 8, Issue 10, 2008

Page: [960 - 967] Pages: 8

DOI: 10.2174/138955708785740652

Price: $65


Alzheimers disease is a complex neurodegenerative disorder with a multifaceted pathogenesis. This fact has long halted the development of effective anti-Alzheimer drugs. Recently, however, basis for a therapeutic strategy based on multi-target-directed ligands has been formed. In this context, dual binding site acetylcholinesterase inhibitors represent a suitable starting point. The rational modification of their structures to provide them with additional biological properties has emerged as a successful approach.

Keywords: Dimeric compounds, bivalent ligands, multimodal therapeutics, multifunctional compounds, multifactorial diseases

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