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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Microwave-Assisted Solid Phase Synthesis of GLP-1-Analogues

Author(s): Yushi Chi, Huibin Zhang, Jinpei Zhou, Wenlong Huang and Shuaijian Ni

Volume 5, Issue 5, 2008

Page: [399 - 402] Pages: 4

DOI: 10.2174/157017808784872061

Price: $65


Gly8-GLP-1 (7∼36) amide and Exendin- 4, analogues of Glucagon-like peptide-1 (GLP-1), were synthesized rapidly and efficiently on rink amide MBHA resin under microwave irradiation, using Fmoc/tBu orthogonal protection strategy. The results showed that the synthesis of the medium- to large-length peptides was greatly improved in the reaction time and the purity of crude product with the use of microwave irradiation.

Keywords: Microwave, GLP-1, solid phase, peptide

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