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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

QSAR Studies on some Calcium Channel Blockers

Author(s): Mallari A. Naik, V. S.A. Kumar Satuluri and S. P. Gupta

Volume 5, Issue 5, 2008

Page: [307 - 312] Pages: 6

DOI: 10.2174/157018008784912090

Price: $65


Quantitative structure-activity relationship studies have been made on some calcium channel blockers (CCBs) that include the most widely studied class of 1,4-dihydropyridines and two new classes of CCBs, namely benzazepinone analogs and quinolizidinyl derivatives. In the case of 1,4-dihydropyridines some simple correlations have been found as compared to those reported in several earlier studies and in the other two classes it could be shown that the electronic parameters and the bulk of the molecules may be important for the activity of the compounds.

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