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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Which Treatment for Nonalcoholic Fatty Liver Disease?

Author(s): S. Moscatiello, R. Marzocchi, N. Villanova, E. Bugianesi and G. Marchesini

Volume 8, Issue 8, 2008

Page: [767 - 775] Pages: 9

DOI: 10.2174/138955708784912193

Price: $65


Subjects with nonalcoholic fatty liver disease are at risk of progressive liver failure. Lifestyle changes including weight-loss strategies and increased physical activity remain the first-line approach, but a few pharmacological treatments have also been successfully tested. Several drugs improve biochemistry, only a few improve histology; in all cases, the results were not sustained after treatment stop. Pharmacological treatment is not so far indicated outside controlled clinical trials with histological outcomes.

Keywords: Orlistat, weight loss, Metformin, statins, Lipid peroxidation, diabetes

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