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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Prediction of Binding Motifs in Hepatitis C Virus NS5A and Human Proteins

Author(s): Guang-Zheng Zhang and Kyungsook Han

Volume 15, Issue 5, 2008

Page: [494 - 504] Pages: 11

DOI: 10.2174/092986608784567500

Price: $65


From the extensive analysis, we identified three highly conserved sequence segments in HCV NS5A proteins and one binding motif in human proteins. The binding motif of human proteins often forms a full helix or an extended strand-loop structure, and is in good agreement with the experimental findings of previous studies.

Keywords: Binding motif, protein-protein interaction, hepatitis C virus, human protein, binding site

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