Abstract
Steroidal glucocorticoids are widely prescribed for the treatment of a variety of inflammatory and autoimmune diseases. Although they are effective, the side-effects associated with chronic glucocorticoid treatment, such as osteoporosis and hyperglycemia, can severely limit their long-term use. Hence, there is a need to develop new effective anti-inflammatory agents for systemic use which are dissociated from their unwanted side effects.
Keywords: SGRM, glucocorticoid, nonsteroidal, modulator, transactivation, transrepression, dissociated, inflammation, multiple myeloma
Current Topics in Medicinal Chemistry
Title: Recent Developments in the Discovery of Selective Glucocorticoid Receptor Modulators (SGRMs)
Volume: 8 Issue: 9
Author(s): Andrew R. Hudson, Steven L. Roach and Robert I. Higuchi
Affiliation:
Keywords: SGRM, glucocorticoid, nonsteroidal, modulator, transactivation, transrepression, dissociated, inflammation, multiple myeloma
Abstract: Steroidal glucocorticoids are widely prescribed for the treatment of a variety of inflammatory and autoimmune diseases. Although they are effective, the side-effects associated with chronic glucocorticoid treatment, such as osteoporosis and hyperglycemia, can severely limit their long-term use. Hence, there is a need to develop new effective anti-inflammatory agents for systemic use which are dissociated from their unwanted side effects.
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Cite this article as:
Hudson R. Andrew, Roach L. Steven and Higuchi I. Robert, Recent Developments in the Discovery of Selective Glucocorticoid Receptor Modulators (SGRMs), Current Topics in Medicinal Chemistry 2008; 8 (9) . https://dx.doi.org/10.2174/156802608784535048
DOI https://dx.doi.org/10.2174/156802608784535048 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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