Modulation by Dopaminergic System of Morphine Withdrawal: In Vitro Evidences

Title: Modulation by Dopaminergic System of Morphine Withdrawal: In Vitro Evidences

Volume: 5 Issue: 4

Author(s): A. Capasso

Affiliation:

Keywords: Dependence, Dopamine, Morphine, Cocaine, Amphetamine, Phencyclidine

Abstract: The effects exerted by cocaine, amphetamine and phencyclidine on the acute opiate withdrawal induced by morphine were investigated in vitro. The results of our experiments indicate that cocaine, amphetamine and phencyclidine are able to influence opiate withdrawal in vitro thus confirming an important functional interaction between the dopaminergic system and opioid withdrawal.

Cite this article as:

Capasso A., Modulation by Dopaminergic System of Morphine Withdrawal: In Vitro Evidences, Letters in Drug Design & Discovery 2008; 5 (4) . https://dx.doi.org/10.2174/157018008784619906