Abstract
A series of 2,4- and 4,6-diaminopyrimidines were prepared and evaluated for their in vitro antimalarial activity. Of the 12 compounds tested 7 showed reasonable activity with 1 having a sub-micromolar IC50.
Keywords: Antimalarial, Diaminopyrimidine, Structure-activity relationship
Letters in Drug Design & Discovery
Title: Antimalarial Activity of 2,4-Diaminopyrimidines
Volume: 5 Issue: 4
Author(s): J. Morgan, R. Haritakul and P. A. Keller
Affiliation:
Keywords: Antimalarial, Diaminopyrimidine, Structure-activity relationship
Abstract: A series of 2,4- and 4,6-diaminopyrimidines were prepared and evaluated for their in vitro antimalarial activity. Of the 12 compounds tested 7 showed reasonable activity with 1 having a sub-micromolar IC50.
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Cite this article as:
Morgan J., Haritakul R. and Keller A. P., Antimalarial Activity of 2,4-Diaminopyrimidines, Letters in Drug Design & Discovery 2008; 5 (4) . https://dx.doi.org/10.2174/157018008784619843
DOI https://dx.doi.org/10.2174/157018008784619843 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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