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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Synthesis and Biological Evaluation of N-Phosphoryl Dipeptide Derivatives as Potent Apoptosis Inducers

Author(s): Xiaoqing Yu, Chunyan Tan, Nan Zhang, Wei Xu and Yuyang Jiang

Volume 15, Issue 4, 2008

Page: [356 - 359] Pages: 4

DOI: 10.2174/092986608784246461

Price: $65

Abstract

A series of N-phosphoryl dipeptide derivatives with trimethoxyaniline moiety were synthesized, in which compound 2a DIPP-Val-Phe-Ar exhibited the best inhibitory activity against K562 cells with the IC50 at 9.7 μM. Its antitumor effects are due to the induction of apoptosis which was further confirmed by morphological study and flow cytometry analysis.

Keywords: N-phosphoryl dipeptide derivative, antitumor, apoptosis


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