Synthesis and Biological Evaluation of N-Phosphoryl Dipeptide Derivatives as Potent Apoptosis Inducers

Title: Synthesis and Biological Evaluation of N-Phosphoryl Dipeptide Derivatives as Potent Apoptosis Inducers

Volume: 15 Issue: 4

Author(s): Xiaoqing Yu, Chunyan Tan, Nan Zhang, Wei Xu and Yuyang Jiang

Affiliation:

Keywords: N-phosphoryl dipeptide derivative, antitumor, apoptosis

Abstract: A series of N-phosphoryl dipeptide derivatives with trimethoxyaniline moiety were synthesized, in which compound 2a DIPP-Val-Phe-Ar exhibited the best inhibitory activity against K562 cells with the IC50 at 9.7 μM. Its antitumor effects are due to the induction of apoptosis which was further confirmed by morphological study and flow cytometry analysis.

Cite this article as:

Yu Xiaoqing, Tan Chunyan, Zhang Nan, Xu Wei and Jiang Yuyang, Synthesis and Biological Evaluation of N-Phosphoryl Dipeptide Derivatives as Potent Apoptosis Inducers, Protein & Peptide Letters 2008; 15 (4) . https://dx.doi.org/10.2174/092986608784246461