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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Polyphenols as Potential Inhibitors of Amyloid Aggregation and Toxicity:Possible Significance to Alzheimers Disease

Author(s): S. Bastianetto, S. Krantic and R. Quirion

Volume 8, Issue 5, 2008

Page: [429 - 435] Pages: 7

DOI: 10.2174/138955708784223512

Price: $65


Beta-amyloid (Aβ) likely plays a pivotal role in the etiology of Alzheimers disease (AD). Consequently, Aβ-associated pathways are targets for the development of possible effective AD therapies. This review first updates strategies aimed at the inhibition of Aβ formation and then discusses the role of food-derived polyphenols as putative antiamyloid drugs.

Keywords: Alzheimer's disease, polyphenols, neuroprotection

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