New 3-Aminosteroid Derivatives as a New Family of Topical Antibacterial Agents Active against Methicillin-Resistant Staphylococcus aureus (MRSA)

Title: New 3-Aminosteroid Derivatives as a New Family of Topical Antibacterial Agents Active against Methicillin-Resistant Staphylococcus aureus (MRSA)

Volume: 5 Issue: 3

Author(s): Chanaz Salmi, Celine Loncle, Nicolas Vidal, Michele Laget, Yves Letourneux and Jean Michel Brunel

Affiliation:

Keywords: Squalamine, Aminosteroid derivatives, Antibacterial agents, Resistance, MRSA

Abstract: A series of new 3-aminosteroid derivatives was evaluated for their in vitro antimicrobial properties against human pathogens such as Gram positive bacteria. They are active against multi-resistant cocci, especially Methicillin- Resistant Staphylococcus aureus (MRSA) at average concentrations of 2.5-5.0 μg/mL and are particularly suitable for topical antibacterial use.

Cite this article as:

Salmi Chanaz, Loncle Celine, Vidal Nicolas, Laget Michele, Letourneux Yves and Brunel Michel Jean, New 3-Aminosteroid Derivatives as a New Family of Topical Antibacterial Agents Active against Methicillin-Resistant Staphylococcus aureus (MRSA), Letters in Drug Design & Discovery 2008; 5 (3) . https://dx.doi.org/10.2174/157018008784084018