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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Microwaves-Assisted Syntheses of Imidazolylbenzamides and their Antioxidant Activities

Author(s): Khalid Mohammed Khan, Uzma Rasool Mughal, Iman Omar and M. Iqbal Choudhary

Volume 5, Issue 3, 2008

Page: [152 - 157] Pages: 6

DOI: 10.2174/157018008784083974

Price: $65


Antioxidant potential of nineteen imidazolones derivatives has been evaluated and their structure-activity relationships established. A rapid and efficient synthesis of imidazolylbenamides was achieved from different azalactones (oxazolones) by reacting with phenyl hydrazide in basic media under microwave irradiation. Excellent yields, high purity, short reaction time and easy and simple work-up are the main features of this synthesis.

Keywords: Microwave-assisted synthesis, Imidazolylbenzamides, Antioxidant, Nitric Oxide

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