Microwaves-Assisted Syntheses of Imidazolylbenzamides and their Antioxidant Activities

Khalid   Mohammed   Khan; Uzma   Rasool   Mughal; Iman      Omar; M.   Iqbal   Choudhary

Abstract

Antioxidant potential of nineteen imidazolones derivatives has been evaluated and their structure-activity relationships established. A rapid and efficient synthesis of imidazolylbenamides was achieved from different azalactones (oxazolones) by reacting with phenyl hydrazide in basic media under microwave irradiation. Excellent yields, high purity, short reaction time and easy and simple work-up are the main features of this synthesis.

Keywords: Microwave-assisted synthesis, Imidazolylbenzamides, Antioxidant, Nitric Oxide