Biological and Pharmacological Activities of Iridoids: Recent Developments

Rosa      Tundis; Monica   R.   Loizzo; Federica      Menichini; Giancarlo   A.   Statti; Francesco      Menichini

Abstract

Iridoids represent a large group of cyclopenta[c]pyran monoterpenoids that occur wide-spread in nature, mainly in dicotyledonous plant families like Apocynaceae, Scrophulariaceae, Diervillaceae, Lamiaceae, Loganiaceae and Rubiaceae. Recently, more extensive studies revealed that iridoids exhibit a wide range of bioactivity, such as neuroprotective, antinflammatory and immunomodulator, hepatoprotective and cardioprotective effects. Anticancer, antioxidant, antimicrobic, hypoglycaemic, hypolipidemic, choleretic, antispasmodic and purgative properties were also reported. The aim of the present review is to discuss the recent developments on biological and pharmacological activities of iridoids, supporting the new therapeutic possibilities for the use of these compounds.

Keywords: Iridoids, secoiridoids, neuroprotection, antitumor, anti-inflammatory, aglycones, glycosides, other biological properties