Synthesis and Antitubercular Evaluation of N-[(E)-(hydroxy, methoxy and ethoxy-substituted-phenyl) Methylidene]isonicotinohydrazide Derivatives

Title: Synthesis and Antitubercular Evaluation of N-[(E)-(hydroxy, methoxy and ethoxy-substituted-phenyl) Methylidene]isonicotinohydrazide Derivatives

Volume: 5 Issue: 2

Author(s): Marcelle de L. Ferreira, Laura N. de F. Cardoso, Raoni S.B. Goncalves, Emerson T. da Silva, Maria Cristina S. Lourenco, Felipe R. Vicente and Marcus V.N. de Souza

Affiliation:

Keywords: Tuberculosis, Multidrug-resistance, Isoniazid, Isonicotinohydrazides, Antimycobacterial activity, Alamar Blue assay

Abstract: The present article describes a series of eighteen N-[(E)-(hydroxy, methoxy and ethoxy substitutedphenyl) methylidene]isonicotinohydrazide derivatives, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in μg/ml. Compounds 2a, 2d-f, and 2h exhibited a significant activity (0.31-1.25 μg/ml) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good start point to find new lead compounds in the fight against multi-drug resistant tuberculosis.

Cite this article as:

Ferreira L. Marcelle de, de F. Cardoso N. Laura, Goncalves S.B. Raoni, da Silva T. Emerson, Lourenco S. Maria Cristina, Vicente R. Felipe and de Souza V.N. Marcus, Synthesis and Antitubercular Evaluation of N-[(E)-(hydroxy, methoxy and ethoxy-substituted-phenyl) Methylidene]isonicotinohydrazide Derivatives, Letters in Drug Design & Discovery 2008; 5 (2) . https://dx.doi.org/10.2174/157018008783928472