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Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued)


ISSN (Print): 1871-5222
ISSN (Online): 1875-6115

Nitric Oxide-cGMP Signaling: Its Role in Cell Junction Dynamics During Spermatogenesis

Author(s): Dolores D. Mruk, Oli Sarkar and Premendu P. Mathur

Volume 8, Issue 1, 2008

Page: [28 - 35] Pages: 8

DOI: 10.2174/187152208783790741

Price: $65


During spermatogenesis, development of spermatogonia into elongated spermatids takes place in the seminiferous epithelium of the adult mammalian testis. Specifically, post-meiotic germ cell maturation occurs in a unique microenvironment sequestered from the systemic circulation by the blood-testis barrier (BTB), which is formed by adjacent Sertoli cells. Therefore, an intact BTB, as well as stable Sertoli-germ cell adhesion, are important criteria for successful spermatogenesis. To date, numerous factors have been shown to influence spermatogenesis, and among them is the well-studied nitric oxide (NO)/guanosine 3,5-cyclic monophosphate (cGMP) signaling cascade. The enzymes of this pathway, namely nitric oxide synthase, soluble guanylate cyclase and cGMP-dependent protein kinase, have all been shown to regulate cell junctions in the testis. Likewise, recent findings have shown that this signaling cascade also plays a critical role in the regulation of Sertoli-germ cell adhesion. In this mini-review, we briefly discuss the regulatory role of each protein component of the NO/cGMP pathway in the context of testicular junction dynamics, as well as their importance in fertility and male contraception.

Keywords: Testis, tight junctions, adherens junctions, nitric oxide signaling pathway

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