Selected Players in the Inflammation Cascade and Drugs That Target These Inflammation Genes Against Metastasis

Title: Selected Players in the Inflammation Cascade and Drugs That Target These Inflammation Genes Against Metastasis

Volume: 6 Issue: 5

Author(s): Shanavas Alikunju and Sivaram Pillarisetti

Affiliation:

Keywords: Cancer, Cytokines, Inflammation, Metastasis, Proteoglycans, TNF

Abstract: Despite many recent advances the prognosis of cancer patients with metastasis still remains poor. In metastatic invasion, tumor cells interact with endothelial cells through several distinct adhesion molecules. Adherent tumor cells extravasate into tissues by degrading basement membranes with matrix degrading enzymes such as heparanases and matrix metalloproteinases. Endothelial expression of matrix degrading enzymes and adhesion molecules are under the control of inflammatory cytokines. These inflammatory proteins and the signaling pathways involved in the expression of these genes are under intense investigation as therapeutic targets to prevent tumor growth and metastasis. The current review focuses on selected players of the inflammation cascade and drugs that target these inflammatory genes.

Cite this article as:

Alikunju Shanavas and Pillarisetti Sivaram, Selected Players in the Inflammation Cascade and Drugs That Target These Inflammation Genes Against Metastasis, Anti-Cancer Agents in Medicinal Chemistry 2006; 6 (5) . https://dx.doi.org/10.2174/187152006778226477