Abstract
Oxidative stress (OS) occurs with an overabundance of reactive oxygen species (ROS) generation and the inability of scavengers, i.e. antioxidants, to neutralize excessive loads of ROS. OS has a role in the etiopathologenesis of many factors causing natural infertility. Infertility is a problem of great magnitude affecting 6 million American women. The etiologies of unexplained infertility and recurrent pregnancy loss remain unclear and present a scientific challenge. Oxidative stress may be a piece in this puzzle. Although investigation of the exact mechanisms by which OS causes pathological processes affecting female fertility is ongoing, research has clearly shown that the redox state affects gametes, their interactions, and the resultant embryo. OS has adverse effects on assisted fertility including IVF/ICSI and in-vitro maturation. This article addresses the role of OS in female infertility, the effect it has on assisted reproductive techniques, and OS prevention strategies including the use of in-vivo and in-vitro antioxidant supplementation.
Keywords: superoxide dismutase, DNA damage, in vitro fertilization, ROS scavengers, Spermatozoa
Call for Papers in Thematic Issues
RARE CASES IN GYNECOLOGY-OBSTETRICS
With the development of diagnostic and therapeutic techniques (such as ART techniques) and the immersion of new pathologies (such as COVID19), we are witnessing an increase in the incidence of pathologies that were previously described as rare or exceptional. the practitioner sometimes confronts difficult situations in these cases in diagnostic ...read more
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